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Berkeley, California, 1933. In a lab filled with curiosities–beakers, microscopes, Bunsen burners, and hundreds upon hundreds of books–sat an investigator who would go on to crack at least two thousand cases in his forty-year career. Known as the “American Sherlock Holmes,” Edward Oscar Heinrich was one of America’s greatest–and first–forensic scientists, with an uncanny knack for finding clues, establishing evidence, and deducing answers with a skill that seemed almost supernatural.

Heinrich was one of the nation’s first expert witnesses, working in a time when the turmoil of Prohibition led to sensationalized crime reporting and only a small, systematic study of evidence. However with his brilliance, and commanding presence in both the courtroom and at crime scenes, Heinrich spearheaded the invention of a myriad of new forensic tools that police still use today, including blood spatter analysis, ballistics, lie-detector tests, and the use of fingerprints as courtroom evidence. His work, though not without its serious–some would say fatal–flaws, changed the course of American criminal investigation.

Based on years of research and thousands of never-before-published primary source materials, American Sherlock captures the life of the man who pioneered the science our legal system now relies upon–as well as the limits of those techniques and the very human experts who wield them.

One of America’s most versatile writers, author of bestselling biographies such as Steve Jobs and Benjamin Franklin, has assembled a gallery of portraits of (mostly) Americans that celebreate genius, talent, and versatility, and traces his own education as a writer and biographer.

In this collection of essays, the brilliant, acclaimed biographer Walter Isaacson reflects on lessons to be learned from Benjamin Franklin, Albert Einstein, Bill Gates, Henry Kissinger, Ronald Reagan and Mikhail Gorbachev, Hillary Clinton and Bill Clinton, and other interesting characters he has chronicled both as biographer and journalist. The people he writes about have an awesome intelligence, but that is not the secret to their success. They had qualities that were even more rare, such as imagination and true curiousity.

Isaacson also reflects on how he became a writer, the lessons he learned from various people he met, and the challenges for journalism in the digital age.

He also offers loving tributes to his hometown of New Orleans, which offers many of the ingredients for a creative culture, and to the Louisiana novelist Walker Percy, who was an early mentor. In an anecdotal and personal way, Isaacson describes the joys of writing and the way that tales about the lives of fascinating people can enlighten our own lives.